21. Landsmøte i kjemi
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ellers er foredragene nummerert etter faggruppe:
- Analytisk kjemi
KI - Kjemometri
- Kvantekjemi og
- Makromolekyl- og
- Organisk kjemi
- Uorganisk kjemi og materialkjemi
Dette dokumentet oppdateres etterhvert som abstractene kommer inn.
Kjemisk Institutt, Universitetet i Oslo
research in inorganic chemistry, I stumbled across hydrogen where and
and everyone else did not expect to find it – it is so common and yet
un-common. It makes bonds more different than any other element – polar
covalent as protons and atoms, metallic when it pleases, and ionic as
ions. Consequently, it shows up in very different forms and locations
and has taken
me for a journey to my roots in physical chemistry and to
some things discovered and some mysteries remaining. Hydrogen holds a
historical role in the establishment of major Norwegian industry, and
host world-leading production of electrolyzers for the emerging markets
hydrogen for storage and as carrier of renewable electrical energy.
of solids contain or may take up water and become solid-state proton
by various mechanisms of transport. They may be used as electrolytes in
types of fuel cells and electrolyzers for hydrogen and renewable
well as in electrocatalytic reactors for upgrading natural gas to
hydrogen with minimal carbon emissions or with carbon capture and
research involves experimental and ab initio computational methods to
hydrogen in its various forms from gas phase, via surfaces and charge
at electrode interfaces, into mobile ions in crystalline or liquid-like
Bottom-up Assembly of Active, Autonomous and Complex
Bioinspired Systems with Adaptive Behaviour
Systems Chemistry, Radboud University Nijmegen, Institute for
Molecules and Materials Nijmegen, The Netherlands
Self-powered artificial motile systems are currently attracting
increased interest as mimics of biological motors but also as potential
components of nanomachinery, robotics, and sensing devices . We have
recently demonstrated a supramolecular approach to design synthetic
nanomotors using self-assembly of amphiphilic block copolymers into
polymersomes and the controlled folding of the vesicles under osmotic
stress into a bowl shape morphology . The folding process can be
precisely controlled to generate different complex architectures 
with adjustable openings and selective entrapment of inorganic
catalysts [4,5] enzymes or multiple enzymes working together in a
metabolic pathway [6,7]. Control of the speed and behaviour of the
nanomotors is possible due to integration of regulatory feedback and
feedforward loops in the enzyme networks designed to preserve energy
and run the motors at even lower concentrations of fuel eg. 0.05 mM
Glucose. Movement in both blood serum and plasma at physiological
concentrations of substrates is consequently demonstrated. The
nanomotor is now not only running at low concentrations of fuel but
also able to regulate it's fuel consumption to achieve the same output
speed showing adaptive behaviour. Recent developments on greater
control over the movement of the nanomotors under chemical gradients or
temperature will be presented [4,7]. Additional manipulation of the
nanomotors under external stimuli and their biomedical applications
will be discussed [6,7].
Acknowledgement. This work was supported in part by the European
Research Council under the European Union's Seventh Framework Programme
(FP7/2007-20012)/ERC-StG 307679 "StomaMotors".
This work was supported in part by the European Research Council under
the European Union's Seventh Framework Programme
(FP7/2007-20012)/ERC-StG 307679 (StomaMotors).
- a) Abdelmohsen, L. K. E. A., Peng, F., Tu, Y. Wilson, D.
Mater. Chem. B., 2014,
2, 2395-2408. (b) Tu, Y. Peng, F. Adawy, A. Men,
Y.; Abdelmohsen, L.K.E.A.; Wilson, D. A. Chem. Rev. 2016, doi:
10.1021/acs.chemrev.5b00344 c) Fei Peng, Yingfeng Tu, Daniela A. Wilson
Chem. Soc. Rev. 2017,
- (a) Wilson, D.A., Nolte, R, J. M., van Hest, J.C.M. Nature
268-274. b) Wilson, D.A., Nolte, R, J. M., van Hest, J.C.M. J.
Am. Chem. Soc., 134,
9894, (2012). (b) Wilson, D.A., de Nijs, B., van
Blaaderen, A., Nolte, R, J. M., van Hest, J.C.M., Nanoscale, 2013, 5,
- (a) R.S.M. Rikken, H. Engelkamp, R.J.M. Nolte, J.C. Maan,
van Hest, D.A. Wilson& P.C.M. Christianen "Shaping
polymersomes into predictable morphologies via out-of-equilibrium
self-assembly", Nat. Commun 2016,
Fei Peng, Nannan Deng, Yingfeng Tu, Jan C.M. van Hest, Daniela A.
Wilson, Nanoscale 2017
DOI: 10.1039/C7NR00142H (b)
- a) Abdelmohsen, L. K. E. A., Nijemeisland, M, Pawar, G. M.
Janssen, G.-J. A. Nolte, R. J. M., van Hest, J. C. M.
Wilson, D.A. *, ACS Nano, 2016,
10 (2), pp 2652-2660. b) Peng, F.
Tu, Y. Pierson, L., van Hest, J. C. M., Wilson, D. A.*, Angew. Chem.
Int. Ed. 2015,
54 (40) 11662-11665
- a) R. Rikken, R.J.M. Nolte, J.C. Maan, J.C M van Hest, D.
Wilson P.C.M. Christianen, Soft Matter, 2013, DOI:
R. Rikken, R.J.M. Nolte, J.C. Maan, J.C M van Hest, P.C.M. Christianen,
D. A. Wilson Chem Commun, 2013,
- a) Rhee, P. G.; Rikken, R. S.; Nolte, R. J. M., Maan, J.
Hest, J. C. M., Christianen, P. C. M. and Wilson, D. A.* Nature Commun.
doi: 10.1038/ncomms6010. b) Fei Peng, Yingfeng Tu, Jan C.M.
van Hest, Wilson, D. A.*, Adv. Mater., 2016, DOI:
- (a) Yingfeng Tu, Fei Peng, Xiaofeng Sui, Paul White, Jan
Hest, Wilson, D. A. Nature. Chem. 2017
DOI: 10.1038/nchem.2674. (b)
Yingfeng Tu, Fei Peng, Alain Andre, Yongjun Men, Daniela A. Wilson*,
ACS Nano 2017, DOI:10.1021/acsnano.6b08079 (c) Fei Peng, Yingfeng Tu,
Ashish Adhikari, Jordi J.C.J Hintzen, Dennis Lowik, Daniela A. Wilson*
Chem Commun 2017, 53, 1088-1091. (d) Fei Peng, Yongjun Men, Yingfeng
Tu, Daniela A. Wilson, Adv. Funct. Mater. 2018, 10.1002/adfm.201706117
(e) Yingfeng Tu, Fei Peng, Paul B. White, Daniela A. Wilson, Angew.
Chem. Int. Ed. 2017, doi: 10.1002/anie.201703276, 56 (26), 7620-7624
Molecular Spin Switches
Otto-Diels Institute for Organic Chemistry, University of
Magnetic bistability at room temperature, such as the orientation of
magnetization used in magnetic storage media, or spin flips in spin
crossover transition metal complexes are typical solid-state phenomena.
Six years ago, we published the first bistable molecular system .
Our spin switches are based on a Ni-porphyrin equipped with a
photochromic azogroup that moves an axial ligand up and down upon
irradiation with violet (430 nm), and green light (530 nm). By changing
the coordination number, the Ni2+ reversibly
changes its spin state
from singlet (diamagnetic) to triplet (paramagnetic). The switching
efficiency in both directions is 100% within the accuracy of NMR and UV
spectroscopy, and there is no fatigue after more than 100 000 switching
cycles. Potential applications are the use as switchable contrast
agents for MRI in interventional radiology for patients suffering from
stroke or myocardial infarction . Further developments are aiming at
measuring temperatures or pH with high spatial 3D resolution by MRI in
To replace Ni2+ by physiologically benign Fe3+,
and to increase the
change in magnetic moment (Ni2+ : ΔS=1, Fe3+ : ΔS=2) we developed a
molecular spin switch based on Fe(III) tetraphenyl porphyrin and a
custom-build azopyridine ligand. Again switching between low-spin
(S=1/2) and high-spin (5/2) is close to quantitative, and no fatigue
was observed after several hundred cycles .
Spin switching in iron porphyrins is the key step in a number of
enzymatic reactions, particularly in C-H activation (e.g. cytochrome
P450). Our system provides the basis for the development of artificial
cytochrome type complexes.
Figure 1: Spin switching
- S. Venkataramani, U. Jana, M. Dommaschk, F. D. Sšnnichsen,
F. Tuczek, R. Herges, Science 2011,
- M. Dommaschk, M. Peters, F.Gutzeit, C. Schuett, C. Naether,
Soennichsen, S. Tiwari,C. Riedel, S. Boretius, R. Herges, J. Am. Chem.
Radionuclides and cancer treatment: How to succeed
Radionuclides have been used for cancer treatment for almost a century.
Initially gamma and beta emitters were used but later alpha emitters attracted
a substantial attention. Criterion for successful product development should be
determined before initiation of the clinical phase of product development. The
product candidate’s chemical and physical properties must be carefully
considered, and synthesis route should be adaptable to industrial scale. The
product candidate must show consistent antitumor activity and acceptable safety
profile in the preclinical tests and dosimetry estimates for human use should
indicate appropriate benefit to risk ratio. Sufficient patent protection is
needed to attract investors.
Radionuclides and properties are addressed, and examples of clinical
products are presented.
Norwegian inventions in the field are presented and the international
trends in the field are discussed.
Integrating cryogenic ion chemistry and spectroscopy: Capture
characterization of reaction intermediates in homogeneous catalysis
The coupling between ambient ionization sources, developed for mass
spectrometric analysis of biomolecules, and cryogenic ion processing,
originally designed to study astrochemistry, creates a new and general
way to capture transient chemical species and elucidate their
structures with optical spectroscopies. Advances in non-linear
optics over the past decade allow single-investigator, table top lasers
to access radiation from 550 cm-1 in the infrared to the vacuum
ultraviolet. When spectra are acquired using predissociation of weakly
bound rare gas "tags", the resulting patterns are
equivalent to absorption spectra and correspond to target ions at
temperatures below 10K. Taken together, what emerges is a new and
powerful structural component to traditional mass spectrometric
analysis. Recent applications ranging from the mechanisms of
small molecule activation by homogeneous catalysts to the microscopic
mechanics underlying the Grotthuss proton relay mechanism in water
emphasize the generality and utility of the methods in contemporary
In photosynthesis, light is used for the production of chemical energy
carriers to fuel biological activity and the water oxidation enzyme
Photosystem II is the first protein complex in the light-dependent
reactions of oxygenic photosynthesis. This presentation will summarise
our progress in the development of protein film photoelectrochemistry
as a technique for the activity of this enzyme adsorbed onto an
electrode surface to be studied. Materials design enabled us to
develop 'tailor-made' 3D electrode scaffolds for optimised
integration of the 'wired' enzyme and these investigations
yielded valuable insights into Photosystem II function. Examples are
the identification of unnatural charge transfer pathways to the
electrode and the elucidation of O2 reduction pathway that
short-circuit the known water-oxidation process.
The integration of Photosystem II in a photoelectrochemical circuit has
enabled the in vitro re-engineering of natural photosynthetic pathways.
We assembled an efficient semi-artificial water splitting cell driven
by light through the rational wiring of Photosystem II to a H2
producing enzyme known as hydrogenase (Figure 1). This hydrogenase
displays unique properties for water splitting applications as it
displays good H2 evolution activity, little product (H2) inhibition and
some tolerance towards O2. The bio-hybrid water splitting cell shows
how we can harvest and utilise electrons generated during water
oxidation at Photosystem II electrodes for the generation of renewable
H2 with a wired hydrogenase through a direct pathway unavailable to
biology. Progress in the assembly of bias-free tandem water splitting
cells with wired enzymes and the integration of robust live
cyanobacteria in 3D structured electrodes will also be discussed.
Figure 1. Schematic
representation of a semi-artificial water splitting system. Water is
photo-oxidized and O2 generated at a Photosystem II-containing
photoanode and aqueous protons are reduced at a hydrogenase-based
cathode. Enzyme-integration was optimised by using a hierarchical ITO
- Kato, Zhang, Paul & Reisner, Chem. Soc. Rev., 2014,
- Zhang, Sokol, Paul, Romero, van Grondelle, &
Reisner, Nature Chem. Biol., 2016, 12, 1046-1052.
- Mersch, Lee, Zhang, Brinkert, Fontecilla-Camps, Rutherford
& Reisner J. Am. Chem. Soc., 2015, 137, 8541-8549.
- Wombwell, Caputo & Reisner, Acc. Chem. Res., 2015,
- Zhang, Bombelli, Sokol, Fantuzzi, Rutherford, Howe
& Reisner, J. Am. Chem. Soc., 2018, 140, 6-9.
KA - Katalyse
Probing Active Species in Catalysis – Application of Advanced
Materials Chemistry, Zernike Institute for Advanced
Materials, University of Groningen, Groningen, The Netherlands email@example.com
Detailed information on the structural and electronic properties of a
catalyst or material and how they change during reaction is required to
understand their reaction mechanism and performance. An experimental
technique that can provide structural as well as electronic analysis
and that can be applied in situ/operando and in a time-resolved mode,
is X-ray spectroscopy. Extended X-ray Absorption Fine Structure (EXAFS)
spectroscopy is powerful in determining the local structure of
compounds including amorphous materials and solutions, since long-range
order is not required. Combined X-ray Absorption and X-ray Emission
spectroscopy (XAS and XES resp.) provides detailed insights in the
electronic properties of a material. Detailed information about the
materials in their dynamic chemical active environment can thus be
obtained and structure/electronic – performance relationships and
reaction mechanisms derived. A combination of spectroscopic techniques
(e.g. UV-Vis, IR) gives complementary information about the system
Over the last years, different approaches have been reported to allow
operando time resolved XAS on catalytic systems, mostly solid-gas. Our
group has developed stopped-flow methodologies allowing simultaneous
time-resolved UV–Vis/XAS experimentation on liquid systems down to the
millisecond (ms) time resolution . Low X-ray energy systems (light
elements) or for low concentrated systems, longer XAS data acquisition
times in fluorescence detection are required and therefore a stopped
flow freeze-quench procedure has been developed . Pushing the
time-resolution has been achieved by synchronizing the synchrotron
bunches with an optical laser in order to perform fast pump-probe
experiments  or micro-reactors for modulation excitation experiments
Developments in XAS using new instrumentation and data acquisition
methods while selecting specific X-ray energies provide this more
detailed electronic information . High energy resolution XAS, XES
and Resonant Inelastic X-ray Scattering (RIXS) provide very detailed
electronic information on the systems under investigation. The
secondary spectrometer design also opens up lab based spectrometer
designs as will be demonstrated.
The methodologies and instrumentation have been developed and applied
to a wealth of materials science, for homogeneous and heterogeneous
catalysis to batteries and fuel cells as well as art objects. In this
lecture, several examples will be given with an emphasis on homogeneous
catalysis, providing insights in activated species and reaction
mechanisms of selective oligomerisation reaction.
- e.g. Tromp M. et al. Organometallics 2010, 29, 3085–3097.
- Bartlett S.A. et al. J. Catal. 2011, 284,
247–258; ACS Catalysis 2014, 4, 4201; Catal. Sci. Techn. 2016, 6, 6237;
Tromp, M. et al, under review.
- Tromp, M. et al. J. Phys. Chem. B 2013, 117(24), 7381–7387.
- Tromp, M. manuscript in preparation.
- e.g. Thomas, R. J. et al. J. Phys. Chem. C 2015, 119(5),
2419–2426; Tromp M. et al, under review.
From Homogeneous to Heterogeneous catalysis: Use of
Microporous Solids as Macroligands
Univ. Lyon, Univ. Claude Bernard Lyon 1, CNRS, IRCELYON - UMR
5256, Villeurbanne, France.
At the molecular scale, the integration of the catalytically active
centers into a solid support without loss of performance compared to
the homogeneous analog is still a major challenge. In this context, a
molecularly defined support as macroligand, i.e. a solid acting like
the ligand in the corresponding molecular complex, can be considered as
a key to bridge the gap between molecular and heterogeneous catalysis.
Metal-Organic Frameworks and purely organic microporous polymers are
promising candidates. In particular, porous frameworks made by the
repetition of a coordinating motif, like the bipyridine motif are of a
high interest as far as bipyridines are widely used as chelating ligand
for molecular catalysts.[1,2]. We show that both homogeneous and
heterogenized catalysts follow the same linear correlation between the
electronic effect of the ligand, described by the Hammett parameter,
and the catalytic activity as exemplified in two reactions. This
correlation highlights the crucial impact of the local electronic
environment surrounding the active catalytic center over the long-range
framework structure of the porous support. The gap between molecular
and heterogeneous catalysis has never been so close to being bridged.
This work is carried out within the H-CCAT project that has received
funding from the European Union’s Horizon 2020 research and innovation
program under grant agreement No 720996. H-CCAT aims at the large scale
production of MOF catalysts and at their use in the industrial
production of pharmaceuticals.
- F. M. Wisser, P. Berruyer, L. Cardenas, Y. Mohr, E. A.
Quadrelli, A. Lesage, D. Farrusseng, J. Canivet, ACS Catal., DOI:
- F. M. Wisser, Y. Mohr, E. A. Quadrelli, D. Farrusseng, J.
Canivet, ChemCatChem, DOI: 10.1002/cctc.201701836 (2018).
HI - Kjemiens historie
KI - Kjemometri
UN - Kjemiundervisning
KM - Kvantekjemi og
MK - Makromolekyl- og
MA - Matkjemi
OR - Organisk kjemi
UM - Uorganisk kjemi og